Pharmacokinetic Comparison - Acitrom® & Warfarin
- Pharmacokinetic Comparison
- Major Highlights
Comparison of pharmacokinetic properties of warfarin and acenocoumarol8,2
Properties | Warfarin | Acenocoumarol |
---|---|---|
Absorption | Rapid | Rapid |
Bioavailability | 99.4% | 60% |
Protein binding | Very high (99%) | Very high (98.7%) |
Halfâlife | Distribution: 6–12 hours Elimination: 20–60 hours (mean 40 hours) | 8–11 hours |
Effect on PT | Within 24 hours | 15–20 hours |
Time to peak plasma concentration | 4 hours | 1–3 hours |
Time to peak effect | 72–96 hours | 36–48 hours |
Duration of action | 2–5 days | 48 hours |
Elimination | Renal 92% | Renal 60% Fecal 29% |
Preparations available | 1 mg, 2 mg, 3 mg, and 5 mg | 0.5 mg, 1–4 mg tablets |
PT, prothrombin time.
The major highlights of the pharmacokinetic properties of acenocoumarol are as follows7,8:
- Acenocoumarol has a rapid onset of action, and the effect is maintained for 15–20 hours. Such properties offer great advantages to its clinical use.
- In most of the patients, it induces the therapeutic prothrombin level 36 hours after the initial dose.
- Therapeutic international normalized ratio values are easy to maintain with single daily dose of acenocoumarol and dose titration of acenocoumarol can be done as per the protocol.
- The raised INR values reverse promptly after the elimination of the single dose of acenocoumarol.
- The anticoagulant effect of acenocoumarol can be counteracted within a few hours with relatively smaller dose of vitamin K1.