Pharmacokinetic Comparison - Acitrom® & Warfarin
- Pharmacokinetic Comparison
- Major Highlights
Comparison of pharmacokinetic properties of warfarin and acenocoumarol8,2
|Protein binding||Very high (99%)||Very high (98.7%)|
|Half‐life||Distribution: 6–12 hours Elimination: 20–60 hours (mean 40 hours)||8–11 hours|
|Effect on PT||Within 24 hours||15–20 hours|
|Time to peak plasma concentration||4 hours||1–3 hours|
|Time to peak effect||72–96 hours||36–48 hours|
|Duration of action||2–5 days||48 hours|
|Elimination||Renal 92%||Renal 60%
|Preparations available||1 mg, 2 mg, 3 mg, and 5 mg||0.5 mg, 1–4 mg tablets|
PT, prothrombin time.
The major highlights of the pharmacokinetic properties of acenocoumarol are as follows7,8:
- Acenocoumarol has a rapid onset of action, and the effect is maintained for 15–20 hours. Such properties offer great advantages to its clinical use.
- In most of the patients, it induces the therapeutic prothrombin level 36 hours after the initial dose.
- Therapeutic international normalized ratio values are easy to maintain with single daily dose of acenocoumarol and dose titration of acenocoumarol can be done as per the protocol.
- The raised INR values reverse promptly after the elimination of the single dose of acenocoumarol.
- The anticoagulant effect of acenocoumarol can be counteracted within a few hours with relatively smaller dose of vitamin K1.